Harris Bernstein Selected Research

Deoxycholic Acid (Sodium Deoxycholate)

7/2014	Novel diet-related mouse model of colon cancer parallels human colon cancer.
8/2011	Carcinogenicity of deoxycholate, a secondary bile acid.
1/2011	Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis.
1/2009	Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis.
3/2007	Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles.
3/2006	Identification of S-nitrosylated proteins after chronic exposure of colon epithelial cells to deoxycholate.
5/2004	A proteomic study of resistance to deoxycholate-induced apoptosis.
3/2003	Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis.
1/2003	Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas.
6/2002	Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients.

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Harris Bernstein Research Topics

Disease

21	Neoplasms (Cancer) 05/2015 - 06/2002
16	Colonic Neoplasms (Colon Cancer) 07/2014 - 03/2002
11	Carcinogenesis 02/2011 - 03/2002
6	Adenocarcinoma 07/2014 - 01/2003
5	Barrett Esophagus (Barrett's Esophagus) 02/2011 - 03/2004
3	Inflammation (Inflammations) 02/2011 - 04/2006
2	Aneuploidy (Aneuploid) 01/2010 - 01/2008
2	Genomic Instability 01/2010 - 01/2008
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 05/2015
1	Adenomatous Polyps 01/2011
1	Polyps 01/2011
1	Adenoma (Adenomas) 05/2010
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 07/2009
1	Esophageal Neoplasms (Esophageal Cancer) 07/2009
1	Colitis 03/2007
1	Reinjuries 12/2006
1	Diarrhea 10/2006
1	Aberrant Crypt Foci 06/2002

Drug/Important Bio-Agent (IBA)

18	Bile Acids and Salts (Bile Acids)IBA 08/2011 - 03/2002
11	Proteins (Proteins, Gene)FDA Link 05/2015 - 06/2002
10	Deoxycholic Acid (Sodium Deoxycholate)IBA 07/2014 - 06/2002
5	DNA (Deoxyribonucleic Acid)IBA 05/2015 - 06/2002
5	Biomarkers (Surrogate Marker)IBA 12/2006 - 12/2002
3	CarcinogensIBA 08/2011 - 03/2002
2	Chlorogenic AcidIBA 07/2014 - 08/2011
2	AntioxidantsIBA 08/2011 - 01/2011
2	SERPIN-B5 (maspin)IBA 01/2011 - 12/2002
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 12/2010 - 09/2005
2	Interleukin-6 (Interleukin 6)IBA 09/2007 - 03/2004
2	RNA (Ribonucleic Acid)IBA 03/2007 - 04/2006
2	Endoplasmic Reticulum Chaperone BiPIBA 03/2003 - 12/2002
1	beta CateninIBA 07/2014
1	Beclin-1IBA 07/2014
1	DNA Repair EnzymesIBA 04/2012
1	Dietary Fats (Dietary Fat)IBA 08/2011
1	MicronutrientsIBA 01/2011
1	MicroRNAs (MicroRNA)IBA 01/2011
1	Oxygen (Dioxygen)IBA 07/2009
1	Reactive Nitrogen SpeciesIBA 07/2009
1	Messenger RNA (mRNA)IBA 02/2009
1	bile acid binding proteinsIBA 02/2009
1	Cytotoxins (Cytolysins)IBA 01/2009
1	Sirolimus (Rapamycin)FDA Link 01/2009
1	MutagensIBA 01/2009
1	AcidsIBA 12/2006
1	Proton Pump InhibitorsIBA 12/2006
1	Enterotoxins (Enterotoxin)IBA 10/2006
1	IonsIBA 10/2006
1	SecretagoguesIBA 10/2006
1	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2006
1	UbiquitinIBA 04/2006
1	A-factor (Streptomyces)IBA 09/2005
1	Apoptosis Regulatory ProteinsIBA 05/2004
1	Nicotine FDA Link 03/2003
1	NF-kappa B (NF-kB)IBA 03/2003
1	XenobioticsIBA 03/2003
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 12/2002
1	TNF Receptor-Associated Factor 2 (TRAF2)IBA 12/2002
1	PeroxiredoxinsIBA 12/2002
1	dolichos biflorus agglutininIBA 06/2002
1	LectinsIBA 06/2002
1	NAD (NADH)IBA 06/2002

Therapy/Procedure

2	Therapeutics 05/2015 - 07/2014